Advanced Liposomal Technology

The key to liposomal delivery is in the protective layer of the liposome’s phospholipids. First, it is vital to understand the structure of phospholipids, as it holds the key to grasping how liposomes work.

In layman’s terms, each phospholipid molecule is made up of a circular “head” that likes water and a “tail” that does not. The heads are attracted to water while the tails try to avoid it, causing the phospholipids to arrange themselves in double-layered lines where the heads are all outside, touching the water, and the tails are “dry” in the encasement they’ve created.

In an aqueous solution (i.e., water), the phospholipids automatically self-assemble so the hydrophobic fatty acid tails (which like to stay dry) move away from water and turn inward, whereas the water-loving phosphate head moves toward the liquid and turns outward. This results in a closed, spherical structure called a liposome with a hollow aqueous core surrounded by a double-layer (bi-layer) membrane, which encapsulates the bioactive (such as L-Lysine) into these microscopic vesicles and protects them from degradation until they are fused into the cells.

The most interesting and beneficial innovation of liposomal delivery technology is that the vesicles are bio-identical to the membranes surrounding human cells. That allows the liposomes to easily penetrate on a cellular level, delivering nutritional payloads (bioactives) directly into the organs, glands and bodily tissues.